[DISCUSIÓN] La teoría de los isómeros

[Goodwalt]

Me corrijo: hay grandes yields de anfeta a partir de p2p en algunas síntesis, por lo que el punto 1 del post original pierde sentido.

Reagents


Phenyl-2-Propanone (P2P) - 138 g (1 mole)
10% Methylamine in Methanol (w/w) - 1000 mL with 100g MeNH2 (~3 moles)
Magnesium Sulfate - 36 g (MgSO4·7H2O, oven dry at 300°C for 2h MgSO4·1H2O) [For drying MeOH/MeNH2 soln]
Silica Gel (3-5 mm balls) - 200 mL (dry at 300°C/2h, they will darken!) [For absorbing 2 mol H2O during rxn]
15 gram NaBH4 as a reducing agent for the formed (waterfree!) imine.

[...]



You have, the last time, snow white crystals. Dry Weight = 141.5 gram, close to quantitative yield.