[EXPERIENCIA] Hongos, primera vez. AA+

[kingF]

Paper 1: https://sci-hub.ee/10.1021/acschemneuro.8b00186 (Geiger et al. 2018, ACS Chem. Neurosci)

   

Once psilocybin (1) is ingested, it is absorbed and undergoes hepatic first-pass metabolism where it is rapidly dephosphorylated into psychoactive psilocin (2) via an unidentified enzyme (Figure 2). Psilocin enters the systemic circulation and crosses into the brain where it may exert its psychoactive effects.

Paper 2: https://sci-hub.ee/10.1080/03602532.2016.1278228 (Dinis Oliveira 2017, Drug Metabolism Reviews)

Psilocybin is primarily a pro-drug that is dephosphorylated by alkaline phosphatase to active metabolite psilocin. This last is then further metabolized, psilocin-O-glucuronide being the main urinary metabolite with clinical and forensic relevance in diagnosis

Magic mushrooms are typically administered per os (drink or in the form of bar of chocolates due to the unpleasant flavor) or smoked. Since it is a zwitterionic alkaloid and due to the presence of a highly polar phosphate group, psilocybin is more soluble in water than psilocin (Ballesteros et al., 2006).

Psilocybin is predominately dephosphorylated in the intestine and liver predominately by alkaline phosphatase to psilocin, which is the main psychoactive compound.

Y solo para ponerlo en un proceso de pregunta: si la psilocibina se desfoforilace en el estómago, por qué funcionaría también preparar una infusión con agua caliente?