hola buenas, encontré este paper THC Prevents MDMA Neurotoxicity in Mice, que habla acerca de los efectos de consumir MDMA en conjunto con canabis. Habían leído información similar? Ahí estoy viendo si encuentro algún otro paper o info pero me pareció muy interesante.
lo más importante a destacar sería esto: " Δ9-tetrahydrocannabinol (THC), the main psychoactive compound of cannabis, has widely reported hypothermic [15], anti-inflammatory [16] and antioxidant [17] properties."...." Several studies in animal models demonstrate that the combination of MDMA and THC counterbalances many of their pharmacological effects. THC attenuated MDMA-induced hyperlocomotion, hyperthermia, and anxiety in rats [18],"..."However, the neuroprotective effects of THC on MDMA neurotoxicity have not yet been explored. The opposite effects of cannabis and MDMA suggest that THC may provide some degree of protection against the neurotoxic effects of MDMA [20], [21]. Therefore, in the present study, we investigate if hypothermic and neuroprotective properties of THC may prevent the neurotoxic effects of MDMA in mice."
lo que implicaría que el canabis podría llegar a ser un gran 'suplemento' a la hora de consumir MDMA.
PD: sino lo pueden abrir pueden probar usando esta app: Unpaywall
[EDIT]
"In summary, THC completely prevents MDMA-induced hyperthermia, glial activation and DA axonal loss by inducing CB1 receptor-mediated hypothermia. THC anti-inflammatory properties mediated by CB2 receptors also reduced microglia and astrocytes activation induced by MDMA. However, THC receptor-independent antioxidant properties do not seem to contribute to reduce MDMA neurotoxicity. Although it has been previously reported that other drugs reducing MDMA-induced hyperthermia also reduced MDMA neurotoxicity [9], these drugs are not used by potential MDMA users. On the contrary, 95% of MDMA users also consume cannabis [14], [21] and, consequently, THC. Some clinical studies have shown that the use of cannabis and MDMA usually results in neurocognitive deficits and neuropsychiatric symptoms, especially in long-lasting heavy users [38]–[40]. However, clinical data suggest the possibility that THC may protect against the neurotoxic effects of MDMA, since several neurological symptoms were attenuated in THC and MDMA consumers when compared to pure MDMA users [21], [41], [42]. Indeed, the use of THC to prevent MDMA-induced hyperthermia and neurotoxicity does not seem to be an adequate measure. However, this study elucidates the consequences of drug polyuse which is one of the main concerns in the study of drugs of abuse, especially MDMA."
en conclusión parece que el THC ayudó con la hyperthermia y además tiene propiedades antiinflamatorias, pero no pareció ayudar a nivel anitoxidación...
peeero también menciona algunos estudios clínicos que indican que el uso de THC y MDMA tiene como resultado algunos deficits neurocognitivos y "neuropsychiatric symptoms, especially in long-lasting heavy users". habría que investigar estos papers qué onda.
[EDIT 2]
dejo varios que fui encontrando para ir poniendomé a tono jajaja, el que se copa podemos ir haciendo tipo metareview... habría que tratar de buscar igual metareviews ya hechos pero no sé bien como se buscan, ya voy a investigar
papers similares:
- Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys 2011
- Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats
- este es del 2004: Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats
papers que citan a este paper:
- el problema de la hipertermia 2016: Effect of crowding, temperature and age on glia activation and dopaminergic neurotoxicity induced by MDMA in the mouse brain
- neourotoxicidad de 2013: Neurotoxicity of MDMA: Main effects and mechanisms
papers que citan a este paper:
- antioxidación dependiendo del sexo 2021: Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences
- Polysubstance use patterns and novel synthetics: A cluster analysis from three U.S. cities
- muy interesante este, efectos a largo plazo del 2015: Learning, Memory, and Executive Function in New MDMA Users: A 2-Year Follow-Up Study
Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences
lo más importante a destacar sería esto: " Δ9-tetrahydrocannabinol (THC), the main psychoactive compound of cannabis, has widely reported hypothermic [15], anti-inflammatory [16] and antioxidant [17] properties."...." Several studies in animal models demonstrate that the combination of MDMA and THC counterbalances many of their pharmacological effects. THC attenuated MDMA-induced hyperlocomotion, hyperthermia, and anxiety in rats [18],"..."However, the neuroprotective effects of THC on MDMA neurotoxicity have not yet been explored. The opposite effects of cannabis and MDMA suggest that THC may provide some degree of protection against the neurotoxic effects of MDMA [20], [21]. Therefore, in the present study, we investigate if hypothermic and neuroprotective properties of THC may prevent the neurotoxic effects of MDMA in mice."
lo que implicaría que el canabis podría llegar a ser un gran 'suplemento' a la hora de consumir MDMA.
PD: sino lo pueden abrir pueden probar usando esta app: Unpaywall
[EDIT]
"In summary, THC completely prevents MDMA-induced hyperthermia, glial activation and DA axonal loss by inducing CB1 receptor-mediated hypothermia. THC anti-inflammatory properties mediated by CB2 receptors also reduced microglia and astrocytes activation induced by MDMA. However, THC receptor-independent antioxidant properties do not seem to contribute to reduce MDMA neurotoxicity. Although it has been previously reported that other drugs reducing MDMA-induced hyperthermia also reduced MDMA neurotoxicity [9], these drugs are not used by potential MDMA users. On the contrary, 95% of MDMA users also consume cannabis [14], [21] and, consequently, THC. Some clinical studies have shown that the use of cannabis and MDMA usually results in neurocognitive deficits and neuropsychiatric symptoms, especially in long-lasting heavy users [38]–[40]. However, clinical data suggest the possibility that THC may protect against the neurotoxic effects of MDMA, since several neurological symptoms were attenuated in THC and MDMA consumers when compared to pure MDMA users [21], [41], [42]. Indeed, the use of THC to prevent MDMA-induced hyperthermia and neurotoxicity does not seem to be an adequate measure. However, this study elucidates the consequences of drug polyuse which is one of the main concerns in the study of drugs of abuse, especially MDMA."
en conclusión parece que el THC ayudó con la hyperthermia y además tiene propiedades antiinflamatorias, pero no pareció ayudar a nivel anitoxidación...
peeero también menciona algunos estudios clínicos que indican que el uso de THC y MDMA tiene como resultado algunos deficits neurocognitivos y "neuropsychiatric symptoms, especially in long-lasting heavy users". habría que investigar estos papers qué onda.
[EDIT 2]
dejo varios que fui encontrando para ir poniendomé a tono jajaja, el que se copa podemos ir haciendo tipo metareview... habría que tratar de buscar igual metareviews ya hechos pero no sé bien como se buscan, ya voy a investigar
papers similares:
- Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys 2011
- Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats
- este es del 2004: Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats
papers que citan a este paper:
- el problema de la hipertermia 2016: Effect of crowding, temperature and age on glia activation and dopaminergic neurotoxicity induced by MDMA in the mouse brain
- neourotoxicidad de 2013: Neurotoxicity of MDMA: Main effects and mechanisms
papers que citan a este paper:
- antioxidación dependiendo del sexo 2021: Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences
- Polysubstance use patterns and novel synthetics: A cluster analysis from three U.S. cities
- muy interesante este, efectos a largo plazo del 2015: Learning, Memory, and Executive Function in New MDMA Users: A 2-Year Follow-Up Study
Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences
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