02-07-2019, 11:15 AM
(29-04-2016, 09:02 PM)Argenpills escribió: Acá un ejemplo de los problemas que puede generar no respetar los dencansos adecuadamente:
Ecstasy (MDMA) and Heart
Drugs such as Ecstasy (MDMA), Heroin and Cocaine all affect the brain. New data show that ecstasy can also damage the heart. Researchers at Louisiana State University, Loyola University and Tulane School of Medicine have discovered that MDMA can change the way the heart works. People who use MDMA often go on "drug binges" when they use the drug frequently, then stop. The scientists tested a similar drug pattern using rats. In the experiments, rats were given MDMA (either 3 mg/kg or 9 mg/kg) twice a day for four consecutive days. After a 10-day period without receiving any drugs, the four-day drug treatment started again. Heart rate, electrocardiogram and blood pressure measurements from each rat were taken before and after the drug treatments. The hearts of rats were also examined under a microscope for damage at the end of the experiment.
After the first drug binge, the rats' heart rate slowed initially, then sped up. After the second and third drug binges, the heart rate slowed even more and blood pressure dropped dramatically. Many (70%) rats showed abnormal heart rhythms after receiving MDMA. Although a single MDMA binge did not result in any apparent heart damage, three MDMA binges caused inflammation of the heart wall.
It is unknown how MDMA causes these heart problems. It is possible that MDMA stimulates the autonomic nervous system which in turn affects the heart. The researchers also suggest that this drug may affect the central nervous system by altering signals in the vagus nerve. Regardless of the mechanism by which Ecstasy affects the heart, it is clear that users of MDMA risk damage to their cardiovascular systems.
Más allá que no sabemos si se puede extrapolar un experimento en ratas en humanos, veo dos problemas en este experimento:
1) se administró la droga por vía inyectable.
2) 3 mg/kg seria aproximadamente 1 pastilla de carga alta para una persona de 80 kgs (240 mg). 9 mg/kg serian 3. Creo que ningún humano consume (1 o 3) dos veces al día durante 4 días seguidos.
Si tomamos el rango menor serían 8 pastillas al día, 32 pastillas cada 2 semanas. En el experimiento esto se repite 3 veces, serían 96 pastillas en 6 semanas (1 mes y medio). Si tomamos el rango mayor serían 96 cada 15 días, 288 pastillas en un mes y medio. Entre 23 y 69 gramos de MDMA en menos de 1 mes y medio, encima por vía inyectable es una LOCURA.
Sería mucho más interesante este experimento con un consumo más acorde a la realidad.